A deep dive into the circulating ctDNA cosmos to vanquish neuroblastoma
Authors
- H.E. Deubzer
- K. Astrahantseff
- M. Lodrini
Journal
- Cancer Discovery
Citation
- Cancer Discov 12 (12): 2727-2729
Abstract
Single biopsies fail to reflect intratumor heterogeneity and tumor evolution. In this issue of Cancer Discovery, Bosse and colleagues show an important role for circulating cell-free tumor DNA sequencing to detect the genomic evolution of neuroblastoma under ALK inhibitor therapy and identify novel (sub)clonal pathogenic variants involved in disease progression under conventional therapy. See related article by Bosse et al., p. 2800 (5).